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We are taking a short break for July. Check back later for our August Webinar details!

No Rosa Webinar for July

K. Melissa Hallow, PhD
Associate Professor, University of Georgia, School of Chemical, Materials and Biomedical Engineering, Athens, GA USA Melissa Hallow is an Associate Professor at the University of Georgia, with joint appointments in the College of Engineering and College of Public Health. She earned her Ph.D. from the Georgia Institute of Technology and worked for several years at Novartis Pharmaceuticals before making the transition to academia at UGA. Her research group uses mathematical models of renal and cardiac physiology and pharmacology to better understand disease processes and drug mechanisms in hypertension, kidney disease, heart failure, and drug-induced kidney injury.
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Multi-scale modeling of multi-organ systems in drug development: a case study on SGLT2 inhibitors

Dr. Robert Sheehan
Senior Modeler, Rosa & Co. LLC
Dr. Colleen Witt
Principal Scientist, Rosa & Co. LLC

A Mechanistic QSP Model of Alzheimer’s Disease Yields Insights into Pathophysiological and Therapeutic Mechanisms

Dr. Michael Monine
Scientific Director, Biogen, Cambridge, MA, US

Prediction of PK/PD for Intrathecally-Administered Antisense Oligonucleotides

Amy Moody, PhD
Senior Principle Scientist, Pfizer, Cambridge, MA

From data driven to theoretical: improving preclinical decision making with modeling

Brian Topp
Senior Director, Merck, Rahway NJ

The Long Road from Discovery to Design

Tom Yankeelov, Ph.D.
W.A. "Tex" Moncrief Chair of Computational Oncology; Director, Center for Computational Oncology, Oden Institute for Computational Engineering and Sciences; Director, Cancer Imaging Research, Livestrong Cancer Institutes; Co-leader, Quantitative Oncology Research Program, Livestrong Cancer Institutes; Adjunct Professor of Imaging Physics, MD Anderson Cancer Center; Professor of Biomedical Engineering, Diagnostic Medicine, Oncology; The University of Texas at Austin, Austin, Texas

Clinical Trials For Patients Who Are Not Average

Norman A. Mazer, M.D., Ph.D.
Founder and Disease Modeling Consultant, NAM Consulting, Basel, Switzerland

The Q-ATN Model of Alzheimer’s Disease: A Work in Progress

Jiawei Zhou, PhD
Pharmacometrician, Pfizer Inc., New York, United States

Understand Tumor Response Heterogeneity in Colorectal Cancer: Share the similarities, celebrate the differences.

Mikael Boberg, PhD
Senior Scientist, AstraZeneca R&D, Gothenburg, Sweden

PK/PD modelling of eflornithine: Assessment of an oral treatment for the fatal parasitic disease human African trypanosomiasis

Sheena Sharma, PhD
Research Investigator, PBPK, Clinical Pharmacology and Pharmacometrics, Bristol Myers Squibb, Lawrenceville, NJ

Proteomics-Informed PBPK Modeling to Predict Systemic and Tissue Drug Concentrations in Rats

Robin T.U. Haid, MSc
PhD Student, Bayer AG, Preclinical Development, Drug Metabolism and Pharmacokinetics, Preclinical Modeling and Simulation / ETH Zurich, Institute of Pharmaceutical Sciences, Biopharmacy

A Pharmacodynamic Model for the Assessment and Optimization of PROTACs

Dr. Marcus Rosenblatt, PhD
Physicist, Institute of Physics, University of Freiburg, Freiburg, Germany

Mechanistic insights into sensitization/desensitization of IFNα signaling and its effect on patient treatment strategies.

Jared Weddell, Ph.D.
Senior Manager, Clinical Pharmacology and Exploratory Development, Astellas Pharma US, Northbrook, IL

A QSP model to understand clinical cytokine dynamics following bispecific dosing in solid tumors

Robert R. Bies, Pharm.D. Ph.D. FISoP
Professor of Pharmaceutical Sciences, Member Institute for Artificial Intelligence and Data Science, University at Buffalo, Buffalo NY

Leveraging machine learning strategies for nonlinear mixed effects model selection (using pyDarwin)

Rebecca Baillie, PhD, Christina Friedrich, PhD, Jake Nichols, PharmD, MBA
Principal Scientist; Chief Engineer, Rosa & Co., San Carlos, CA; Director of Medical Affairs, US WorldMeds, Louisville, KY

Demonstrating Efficacy When Clinical Trials Are Impossible: QSP Modeling to Support a New Dose Application

Natalie Morris, BSc
University of Bristol, Bristol, UK

Defining design rules for next-generation snakebite antivenoms

Vincent Lemaire, Ph.D.; Fei Hua, Ph.D.
Distinguished Scientist Modeling and Simulation, Genentech, South San Francisco, CA; VP, Head of Modeling and Simulation Services, Aplied BioMath Concord, MA

From Cold to Hot: Perceptions of the Use and Impact of QSP in Immuno-oncology – A Survey of the Community and Stakeholders

Dr Dinko Rekic, PhD and Dr Jane Knöchel, PhD
Global Product Leader – ticagrelor; Clinical Pharmacometrician, AstraZeneca, Gothenburg, Sweden

A case‐study of model‐informed drug development of a novel PCSK9 antisense oligonucleotide

The team is taking some time to spend with their families.

No Webinar for December

Chuanpu Hu, PhD
Senior Scientific Director and Fellow, Janssen R&D, LLC

Variability and uncertainty: interpretation and usage of pharmacometric simulations and intervals

Wojciech Krzyzanski PhD, MA
Associate Professor, University at Buffalo

Pharmacodynamic age structured population model for cell trafficking

Philippe Moingeon PhD, MBA
Head of Immuno-inflammation portfolio, Servier

AI-powered modeling approaches to support the development of new therapies for autoimmune diseases

Bill Brastow, Ph.D.
Chief Technology Officer for Rosa Market Modeling

Injecting Reality into Commercial Due Diligence for In-Licensing, Partnering or Purchasing Pharmaceutical Assets in Development

• Christina Friedrich, PhD, Chief Engineer, Rosa & Co, San Carlos, CA• Stephen Duffull, PhD, Professor, (1) Senior Scientific Advisor, Certara, (2) Otago Pharmacometrics Group, School of Pharmacy, University of Otago, Dunedin, New Zealand• Theodor

VPs... You got to know when to hold them, know when to remove them, know when to resample, know when to run.

Stefano Morotti, PhD.
Assistant Professor at University of California Davis

Cross-species translation of drug-induced electrophysiological response in cardiac myocytes

Chuanpu Hu, PhD.
Senior Scientific Director and Fellow at Janssen R&D, LLC

Analyzing Outcome Score Data

Joga Gobburu
Professor, University of Maryland

Predictive Healthcare Analytics

Nick Holford, Emeritus Professor
Emeritus Professor, University of Auckland, New Zealand

Concentration Guided Dosing

Christina Friedrich, PhD; Jérémy Huard
Chief Engineer, PhysioPD, Rosa & Co, LLC; Senior Application Engineer, MathWorks

Using Machine Learning Surrogate Modeling for Faster QSP VP-Cohort Generation

Check back soon for more webinars.

We are taking January off and will resume the webinars in February

Dr. Dipak Barua
Research Principal Scientist, Takeda Pharmaceutical Company Limited

A mechanistic model-based analysis of Fn14 - NF-Kappa B dysregulation in glioblastoma multiforme

James Lu, PhD
Principal AI Scientist, Genentech

Using Machine Intelligence in building PK/PD and Disease Progression Models

Dr Adam Palmer
Assistant Professor of Pharmacology, UNC Chapel Hill

Models to understand and predict the clinical efficacy of combination cancer therapy

Yanguang (Carter) Cao, PhD.
Assistant Professor | University of North Carolina at Chapel Hill

Probing antibody-target interactions in living systems

Tongli Zhang, PhD
Assistant Professor, University of Cincinnati

Integrating Quantitative Systems Pharmacology and Machine learning, why bother?

Anastasios Siokis, PhD
Postdoc in Translational Disease Modeling, Sanofi, Germany

An agent-based simulation platform studying the immunological synapse dynamics

Vincent Hurez, DVM, PhD
Senior Scientist at Rosa & Co LLC

Predicting subjective or complex clinical outcomes in QSP models: challenges and approaches

Thorsten Lehr, PhD
Professor of Clinical Pharmacy, Saarland University


Amber Smith, PhD.
Assistant Professor at The University of Tennessee Health Science Center

The Ravaging Respiratory Infection: Fighting Influenza Using Mechanistic Models

Bill Brastow, PhD
Principal and CTO Rosa Market Modeling


Bill Brastow, PhD
Principal and CTO Rosa Market Modeling

Out of the Lab - Into the Market: Modeling Physician Decision-Making Behavior Using Discrete Choice

Paul B. Watkins, M.D. FAASLD.
Director, Institute for Drug Safety Sciences at the University of North Carolina in Chapel Hill

QST and the Transformation in Drug Safety Assessment

Luca Gerosa, PhD
Postdoctoral Fellow, Laboratory of Systems Pharmacology, at Harvard Medical School

Building Kinetic Models with Complex Drug-Protein Interactions: application to the targeted inhibition of MAPK signaling in cancer

Katherine Kudrycki, PhD
Principal Scientist at Rosa & Co. LLC

Do you need a life scientist for QSP modeling?

Eric Sobie, PhD
Professor, Pharmacological Sciences at Icahn School of Medicine at Mount Sinai

Using QSP to predict cardiotoxicity caused by cancer drugs

Dr. Jonathan E. Allen
Informatics Thrust Leader, Biosecurity Center at ATOM Consortium and Lawrence Livermore National Laboratory

An Integrated Machine Learning Framework for Novel Small Molecule Drug Design

Dr. Bill Brastow
Principal and Chief Technology Officer at Rosa Market Modeling

Driving Market Share for Healthcare Products by Integrating Market Modeling

Stacey Tannenbaum, PhD, FISoP
Senior Director, Pharmacometrics US Clinical Pharmacology and Exploratory Development, Astellas Pharma, Northbrook, IL

Making the 'Moster' of Your Poster

Iraj Hosseini, PhD and Justin Feigelman, PhD
Scientists at Genentech, Inc in South San Francisco

gQSPSim: a SimBiology®-based GUI app for standardized QSP model development and application

Paolo Denti, PhD
Associate Professor at the University of Cape Town

Of “clever” models and “dumb” spreadsheets”: what is more effective to drive policy change?

Sergio Iadevaia, PhD
Scientific Director QSP, Pharmacometrics and Data Analysis at Takeda

Development of a QSP Platform to Quantify Benefits of DAAO Inhibition in Schizophrenia

Rajanikanth (Raj) Madabushi, PhD
Team Lead, Guidance and Policy & CDER Point-of-Contact for the MIDD paired Meeting Pilot Program, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, USFDA

Mainstreaming MIDD: A Holistic and Integrative Approach

Jeffrey R. Sachs, Ph.D.
Senior Principal Scientist, Merck & Co., Inc. based in Kenilworth, NJ, USA, known as MSD outside Canada and USA

MIDD: Vaccine R&D Gets a Shot in the Arm from Pharmacometrics

Sietse Braakman, PhD
SimBiology Application Engineer at MathWorks

A general workflow for parameter estimation to help establish confidence in model predictions

Dr. Britta Goebel
Head of Translational Disease Modeling (Diabetes-CV & I&I) at Sanofi, Frankfurt

Quantitative Systems Pharmacology Modeling Support in Development of Novel Diabetes Treatments

Robert Bies, Pharm.D. Ph.D
Associate Professor of Pharmaceutical Sciences, Member Computational and Data Enabled Sciences Program at the University at Buffalo, NY

Hybrid Genetic Algorithm Approaches to Model Selection

James Yates, MMath, PhD
Principal Scientist, AstraZeneca, Cambridge UK

Attack of the Clones: Understanding the kinetics of resistance to cancer treatment

Maria Trujillo PhD
Principal Scientist, Merck and Co Inc, Kenilworth, NJ

Leveraging a Diabetes QSP Model to Drive Decisions in Target Identification and Validation for Proinsulin to Insulin Conversion Therapy

Loveleena Bansal, PhD
Scientific Leader, GSK Associate Fellow, at GSK, Collegeville PA

Modular development and application of platform QSP models to support a broad R&D portfolio: Examples from immuno-oncology and respiratory therapeutic areas

Vivaswath S. Ayyar, Ph.D.
Adjunct Assistant Professor of Pharmaceutical Sciences, University at Buffalo, NY and PK/PD Scientist, Janssen BioTherapeutics, Spring House, PA

Expanding from Basic Towards Systems Pharmacodynamic Models for Methylprednisolone

Dr.-Ing. Markus Rehberg
Scientist QSP at Sanofi-Aventis Deutschland GmbH

Systems Immunology Modeling: From Mechanistic Details to Clinical Outcomes in Rheumatoid Arthritis

Stephan Schmidt, B.Pharm, Ph.D., F.C.P.
Associate Professor & Associate Director, Center for Pharmacometrics & Systems Pharmacology, University of Florida

Pharmacometrics, PBPK, QSP – What’s Next?

Professor Ioannis (Yannis) P. Androulakis
Rutgers University - Biomedical Engineering

Dynamic Models for Personalized QSP: How models can help us explore big data

Chi-Chung Li, Ph.D., Senior Scientist, Clinical Pharmacology, and Iraj Hosseini, PhD. Scientist
Genentech, Roche, South San Francisco.

Enhancing Phase I Clinical Decision Making Through the Use of Quantitative Systems Pharmacology Modeling: A Case Study of Mosunetuzumab in Relapsed/Refractory Non-Hodgkin’s Lymphoma

Eric Sobie, PhD, Professor, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY

Combining mechanistic modeling with machine learning to predict cardiotoxicity and streamline drug development

Theresa Yuraszeck, Associate Director, Quantitative Pharmacology, CSL Behring

Quantitative Approaches to Informing Clinical Decisions – Where does Systems Pharmacology Fit In?

Richard Gliklich, MD, Founder and CEO, OM1

Advancing Drug Development and Outcomes Research with Artificial Intelligence, Machine Learning, and Predictive Models

Iraj Hosseini, PhD. Scientist at Genentech

The gPKPDsim Simbiology app

Prasad Dhurjati, PhD, Professor of Chemical & Bio-molecular Engineering, Joint appointment as Professor Biological Sciences and Professor of Mathematical Sciences, University of Delaware

System Level Modeling of the Human Gut Microbiome

1) Lealem Mulugeta, Executive Committee Member of CPMS, Founder/Executive of InSilico Labs and Medalist Fitness.2) Andrew Drach, Senior Research Fellow at University of Texas at Austin, Executive Committee Member of CPMS

Ten Simple Rules of Credible Practice of Modeling and Simulation in Healthcare: Application to Bone Remodeling and Heart Valve Modeling

Aman Singh, PK-PD Scientist, Biologics Development Sciences, Janssen R&D

Towards Development of a Systems PK-PD Model to Characterize Bystander Effect of Antibody-Drug Conjugates (ADCs)

Christina Friedrich, PhD, Chief Engineer, and Mike Reed, PhD, Chief Scientist, Rosa & Co, CA

How to Ensure Your QSP Model is Useful – Illustrative Examples and Lessons Learned

Richard A. Gray, PhD, Senior Research Biomedical Engineer, Food and Drug Administration, Silver Spring, MD

The Potential Impact of Physiological Computer Models in Medicine: Regulation and Considerations for Ensuring Patient Safety

Chihiro Hasegawa, PhD, PK/PD Scientist, Ono Pharma, Japan, Otago Pharmacometrics Group, School of Pharmacy, University of Otago, New Zealand

Automated scale reduction of nonlinear QSP models with an example of a bone biology system

Frank Gibbons, PhDPrincipal Scientist, DMPK, IMED Oncology Biotech UnitAstraZeneca

Pulling your model up by its bootstraps: evolving your way to QSP

Sietse Braakman, PhDMathWorks

Enabling QSP and PK/PD workflows using SimBiology and MATLAB: What’s New?

Dr. Ryan TasseffScientistProcter and Gamble

Development of a multiscale skin barrier model for de novo, in silico prediction

Konstantinos (Kostas) Biliouris, PhD Principal Pharmacometrics Scientist Novartis Cambridge, MA, USA

Quantitative Modeling in Support of the Development of a Systemic Lupus Erythematosus Drug

Nelleke Snelder Senior Consultant LAP&P Consultants BV Leiden, The Netherlands

QSP modelling - at the heart of the action.

Joga Gobburu, PhD, Division of Parmacometrics, OCP/FDA

Learn & Apply Paradigm in Drug Development: How disease-drug-trial models can aid decisions

Dr. Valeriu Damian-Iordache, Director Pharmacokinetics and Translational Biology, GlaxoSmithKline

Physiological based modeling for ocular drug delivery

Dr. Scott Q Siler, Lead DILI-sim Consultant

The DILIsym™ model and its application to hepatotoxicity testing in drug development

Dr. Toufigh Gordi, Rosa and Co.; President, PK/PD and Clinical Pharmacology Services

Mechanistic PK/PD Modeling in Pediatrics

Dr. Birgit Schoeberl; Vice President of Discovery; Merrimack Pharmaceuticals

Using mathematical models to set design criteria for antibody-based therapies

Joga Gobburu, PhD FCP MBA; School of Pharmacy|School of Medicine, Univ. of Maryland, Baltimore

Impact of Pharmacometric Analyses on New Drug Approval and Labelling Decisions

Hartmut Derendorf, PhD; University of Florida, Gainesville

PK/PD-based Development of Anti-infective Agents

Tristan Maurer, PharmD, PhD; Research Fellow at Pfizer Pharmaceuticals

Translational Modeling & Simulation in Support of Rational Drug Discovery: Principles, Challenges and Examples

William J. Jusko, PhD, SUNY (Buffalo)

Moving PK/PD From Basic Towards Systems Pharmacology

Christina Friedrich, PhD, Rosa & Co

Developing Models that are Fit for Purpose — A Model Qualification Method

Nick Holford, MBChB, University of Auckland, New Zealand

Clinical Pharmacology = Disease Progression + Drug Action

Herbert Sauro, PhD, University of Washington, Seattle

Standards and Software in Biomedical Systems Modeling

Rebecca Baillie, PhD, Rosa & Co

How to build a PhysioPD model

Rada Savic, PhD, Uppsala University

Overview of modeling tools in drug development

Dr. Frank Bergmann, University of Heidelberg

Applying the Scientific Method to Simulation Experiments

Tarek Leil, Director, Bristol-Myers Squibb

A Bayesian Perspective on Estimation of Variability and Uncertainty in Mechanism-Based Models

Robert Leipold, Research Scientist, Evidera

Modeling in Healthcare Economic Evaluations

Dean Bottino, Head Modeling & Simulation Oncology at Roche Pharmaceuticals

Multi-scale modeling to optimize the antitumor effect of antibody-dependent cell-mediated cytotoxicity (ADCC) enhanced therapies

Michael A. Eldon, Principal Scientific Fellow, VP, Clinical Pharmacology, Nektar Therapeutics

PK/PD Modeling and simulation: Applications in discovery through development

Christina Friedrich, Chief Engineer, Rosa and Co.

Learnings from the Field: The Rosa Physiological Model Qualification Method

David J. Klinke II, Ph.D, Associate Professor, Chemical Engineering; West Virginia University

In silico model-based inference: A contemporary approach for hypothesis testing in systems

Dr. Chee Ng, Assistant Professor at Children's Hospital of Philadelphia

Model-based Discovery/Development of Therapeutic Monoclonal Antibodies

Dhavalkumar Shah, Senior Scientist; Modeling & Simulation, Pharmacokinetics, Dynamics, and Metabolism; Pfizer

Bench to Bedside Translation of Antibody Drug Conjugates Using a Multiscale Mechanistic PK/PD Model: A Case Study with SGN-35

Arthur Lo, Senior Scientist; Theravance

Integration of in vitro data into a viral kinetics model to investigate rapid development of Hepatitis C resistance to therapy

Pratap Singh, Ph.D, Senior Principal Scientist, Pfizer

Role of Myostatin in Muscle Growth: Key Learnings From PK/PD Modeling Analysis

Malcolm Rowland, PhD, Professor Emeritus, University of Manchester

Addressing drug development questions with physiologically based pharmacokinetics

Dr. Richard Peck, Global Head Clinical Pharmacology, Pharmaceutical Research and Development (pRED), Roche Products Ltd

How can We Use Mechanism-based Receptor Models for Designing First in Human Studies?

Mike Reed, Chief Scientist, PhysioPD, Rosa & Co

Building and Using a Quantitative Systems Pharmacology Model: Overview and Case Study

Hugo Geerts Scientific Liaison Officer at In Silico Biosciences

Quantitative Systems Pharmacology in CNS Disorders Providing value for Pharmaceutical R&D in Neurology and Psychiatry

Dhaval Shah Assistant Professor at SUNY Buffalo

Evolution of the Platform PBPK Model for Monoclonal Antibodies Towards Pediatric Population

Marc Birtwistle, PhD; Asst Professor, Pharmacology and Systems Therapeutics, Icahn School of Medicine, Mount Sinai, NY

Noise and Signaling in Cancer Systems Pharmacology

Yu-Nien (Tom) Sun, Director, Quantitative Pharmacology Group; Pharmacokinetics & Drug Metabolism Department, Amgen, Inc.

Model-Based Drug Development for Oncology Therapeutics

Kapil Gadkar, Scientist at Genentech

A mechanistic systems pharmacology model for prediction of LDL cholesterol lowering by anti-PCSK9 in human dyslipidemia

C.J. Musante, Associate Research Fellow, Cardiovascular and Metabolic Diseases; Gianluca Nucci, Senior Director, Clinical Pharmacology, and Mark Peterson Director, Pharmacometrics, Pfizer Inc.

Quantitative Systems Pharmacology at Pfizer: A Paradigm Shift to Improve the Probability of Successful Proof of Concept Studies

Thierry Lave, Head DMPK and TOX Project Leader and Modeling and Simulation, F. Hoffmann-La Roche

Translational modeling in support of nonclinical safety assessments

Ron Beaver, PhD, Founder, Chairman, and CEO, Rosa & Co LLC

Systems Pharmacology: Science or Non-science? And so what?

Dr. Yanguang Cao, Research Assistant Professor, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY

Applications of minimal PBPK models to small and large molecules

Kosmas Kretsos, Associate Director, Global Exploratory Development, UCB New Medicines

Differentiate or die: Preclinical and early clinical assessment of differentiation potential via modeling

Stephen Duffull, PhD, Chair of Clinical Pharmacy, Otago Pharmacometrics Group, School of Pharmacy, University of Otago, Dunedin, New Zealand

Systems models–their use and simplification

Ananth Kadambi, Ph.D., Senior Vice President, PhysioPD™, Rosa & Co.

Differential applications of Quantitative Systems Pharmacology and traditional modeling approaches in pharmaceutical R&D

Satyaprakash Nayak (Satya), Pharmacometrician - Systems Biologist at Pfizer

Development of a Quantitative Systems Pharmacology Model of the Blood Coagulation Network & its Application to Clinical Programs

Peter L. Bonate, PhD, Senior Director, Astellas; Global Head - Pharmacokinetics, Modeling, and Simulation; Global Clinical Pharmacology & Exploratory Development

Modeler Tailor Listener Buy

Eric A. Sobie Ph.D., Associate Professor, Dept. of Pharmacology and Systems Therapeutics; Icahn School of Medicine at Mount Sinai, NYC, NY

Quantitative Cardiovascular Systems Pharmacology: Exploiting mathematical models to generate novel insight

Loveleena Bansal, PhD, Post-Doctoral Researcher, GlaxoSmithKline

A Quantitative Systems Pharmacology (QSP) Approach to Understand the Pathogenesis of Acne and Evaluate New Acne Therapies

Dr. Ioannis (Yannis) P. Androulakis, Professor, Rutgers University, Piscataway, NJ

Systems engineering meets Quantitative Systems Pharmacology: From low-level targets to engaging the host defenses

Samik Ghosh, PhD, The Systems Biology Institute, Tokyo, Japan

Garuda: Fly to the future of biology

Sandra Visser, Principal Scientist, Early Stage Quantitative Pharmacology & Pharmacometrics, Merck

Bringing Quantitative and Systems Pharmacology to Drug Discovery: Implementation, Impact, and Challenges

Michael Bolger, Ph.D., Chief Scientist and Ted Grasela, Ph.D., President, Simulations Plus; Lancaster, CA

Applying QSAR and PBPK Modeling to Bridge Discovery and Assessment of Clinical Potential

Helen Moore, PhD, Associate Director, Quantitative Clinical Pharmacology, Bristol-Myers Squibb, Princeton, NJ

Mathematical Optimization of Combination Therapy Regimens

Christina Friedrich, PhD, Chief Engineer, Rosa & Co., San Carlos, CA and Fulden Buyukozturk, PhD, Technical Evangelist, MathWorks; Natick, MA

MATLAB and SimBiology facilitate QSP modeling and analysis to support drug development

Melissa Hallow, Ph.D., Assistant Professor, College Of Engineering And Department Of Epidemiology And Biostatistics, University of Georgia, Athens, GA

Application of Physiology - Disease-Drug Model of Kidney Disease

Jonathan Wagg, MD, PhD, Disease Therapeutic Area Modeling Leader – Oncology, Roche Pharmaceutical Research and Early Development

Optimizing Delivery of Cancer Vaccines: Short Peptides Insights from Disease Modelling

Oliver Ghobrial, Sr. Scientist III, Systems Pharmacology/DMPK/PKPD, AbbVie, Inc.

AbbVie Dermatology QSP Platform: Build Strategy and Applications in Psoriasis Drug Discovery and Clinical Development

Dr. Lourdes Cucurull-Sanchez, Senior Scientific Investigator; GlaxoSmithKline

Modelling Cytokine Receptors as Drug Targets – A Case Study

Valeriu Damian, DirectorSystems Modeling and Translational Biology GlaxoSmithKline, King of Prussia, PA

QSP - What’s in it for me? Case study examples

Dr. Herbert Sauro, Associate Professor, Bioengineering, University of Washington

Approaches to Reproducibility in Systems and Physiological Modeling

Aman P. Singh, PhD CandidateDepartment of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY

A PK-PD Modeling and Simulation Based Strategy for Clinical Translation of Antibody-Drug Conjugates: A case study with T-DM1

Dr. Michael Weis, Senior Engineer, PhysioPD™, Rosa & Co.

Considerations for adopting models for PhysioPD-style Research

Stacey Tannenbaum, PhD, FISoP Director: Pharmacokinetics, Modeling, and Simulation Clinical Pharmacology & Exploratory Development Astellas Pharma Global Development; Northbrook, IL

Pharmacometricians and Statisticians in Drug Development: Can’t We All Just Get Along?

Natal van Riel, MSc, PhD Professor Computational Modelling Associate Professor Systems Biology and Metabolic Disease Eindhoven University of Technology, and Amsterdam Medical Center Eindhoven, The Netherlands

Quantification of Variability and Uncertainty in Multi-Level Systems Pharmacology Models

Ben-Fillippo Krippendorff, Ph.D.Quantitative Systems Pharmacology, Pharmaceutical SciencesRoche Pharma Research & Early DevelopmentRoche Innovation Center Basel

Predicting Tissue Distribution and Clearance of Large Molecules to Improve Selectivity of Targeted Therapies

Craig Thalhauser, Ph.D., Associate Director/Quantitative Clinical Pharmacology, Bristol-Myers Squibb, Princeton, NJ

Calibration, Validation, and Responder Analysis in a Virtual Population of Rheumatoid Arthritis Patients