Systems models–their use and simplification
Stephen Duffull, PhD, Chair of Clinical Pharmacy, Otago Pharmacometrics Group, School of Pharmacy, University of Otago, Dunedin, New Zealand
Formal methods of meta-analysis for review of effect size for clinical trials are well established methodologies for hypothesis testing. More recently models of pharmacological systems have gained credence as methods for generating hypotheses. Both meta-analysis and systems models rely on analysis of prior information. This talk will review the development and use of a systems pharmacology model for learning about coagulation and drugs that affect coagulation. Its use as a hypothesis generating tool will be explored with reference to safety of newer anticoagulants, identification of targets for monitoring low molecular weight heparins and understanding the influence of pro-coagulant toxins on patient recovery.