Bringing Quantitative and Systems Pharmacology to Drug Discovery: Implementation, Impact, and Challenges

Model-informed drug discovery uses quantitative and translational pharmacology to build and continuously improve the quantitative understanding of the relation between drug exposure, target engagement, efficacy, and safety in drug discovery. This webinar will discuss how quantitative and translational pharmacology can enable understanding of key compound properties for optimization, streamline research operating plans, improve in vivo experimental design, and set PKPD targets for human dose predictions and safety margins. Drug discovery implementation, key concepts, impact examples, and challenges are discussed.