Ten Simple Rules of Credible Practice of Modeling and Simulation in Healthcare: Application to Bone Remodeling and Heart Valve Modeling
1) Lealem Mulugeta, Executive Committee Member of CPMS, Founder/Executive of InSilico Labs and Medalist Fitness.2) Andrew Drach, Senior Research Fellow at University of Texas at Austin, Executive Committee Member of CPMS
Computational modeling and simulation (M&S) has the potential to play a critical role in precision medicine and personalized healthcare. However, there are few formalized processes and procedures to support the credible use of M&S in healthcare and biomedical research, limiting their adoption. To address this gap, the Committee on Credible Practice of Modeling & Simulation in Healthcare (CPMS) was established under the Interagency Modeling and Analysis Group (IMAG) and the Multiscale Modeling (MSM) Consortium, which includes representatives from government agencies such as the National Institutes of Health, NASA, and the U.S. Food and Drug Administration. One of CPMS’ primary goals is to develop “The Ten Simple Rules of Credible Practice of M&S in Healthcare.” These rules were derived via synthesis of the Committee’s expertise in this domain and by surveying the global stakeholder community to ensure a balanced representation of interests and perspectives concerning credible practice of M&S in healthcare.
This presentation will introduce these rules, present two case studies (modeling heart valves and bone remodeling) to demonstrate their value, and discuss strategies for incorporating these rules into workflows.