After 22 years, Rosa & Co. has created mechanistic models in a number of therapeutic areas and modalities. We have published a number of models when allowed by sponsors. However, an extensive list is available at the Disease Area page. To learn more, please reach out to us via our Contact page. Our models have helped the decision process throughout the drug discovery and development process, including disease modeling, mechanism exploration, target selection, lead optimization, pre-clinical experiment design, and throughout the clinical trial process (dose selection, combination therapies, biomarkers, product comparison, regimen optimization, etc). Below is the list of therapeutic and disease areas that Rosa & Co. have experience in:
Autoimmune Diseases: Interstitial Cystitis, Primary Sjogren's Syndrome, Psoriasis, Rheumatoid Arthritis, Systemic Lupus Erythematosus
Cardiovascular Diseases: Atherosclerosis, Dyslipidemia, Hypertension
Central Nervous System Diseases: Alzheimer's Disease, Emesis, Frontotemporal Dementia, Multiple Sclerosis, Opioid Overdose Reversal, Pain, Parkinson's Disease, Schizophrenia, Vasomotor Symptoms
Dermatology: Acne, Atopic Dermatitis, Dermis/Aging, Erythema, Psoriasis
Gastroenterology: Celiac Disease, Drug-induced Colitis, Inflammatory Bowel Disease
Immuno Oncology: Acute Lymphoblastic Leukemia, Ewing's Sarcoma, Melanoma, Metastatic Melanoma, Non-Hodgkin's Lymphoma, Non-Small Cell Lung Cancer, Pancreatic Cancer
Immunology: Acute Kidney Injury, Acute Respiratory Distress Syndrome, Celiac Disease, Endometriosis, Fibrosis, Sepsis, Sjogren's Disease, Stroke, Systemic Lupus Erythematosus, Vasculitis
Metabolic Diseases: Cushing's Disease, Glycogen Storage Disease, Hypoglycemia, Type 1 Diabetes, Type 2 Diabetes, Urea Cycle Disorder,
Oncology: Acute Myeloid Leukemia, Breast Cancer, Colorectal Cancer, Diffuse Large B Cell Lymphoma, Gastrointestinal Stromal Tumor, Lymphoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer
Rare Diseases: Glycogen Storage Disease, Hematology, Urea Cycle Disorder, Renal Diseases, Autosomal-Dominant Polycystic Kidney Disease, Chronic Kidney Disease
Respiratory: Asthma, COPD