Bench to Bedside Translation of Antibody Drug Conjugates Using a Multiscale Mechanistic PK/PD Model: A Case Study with SGN-35
Dhavalkumar Shah, Senior Scientist; Modeling & Simulation, Pharmacokinetics, Dynamics, and Metabolism; Pfizer
The presentation will lay out a step by step approach to build and validate a novel, multiscale, mechanism-based PK/PD model for antibody drug candidates (ADCs). The model is designed to integrate pre-clinical biomeasures and PK/PD data to provide pre-clinical-to-clinical translation of ADC efficacy. The presentation will highlight that it is essential to understand and characterize the disposition of ADC and payload, at cellular and physiological levels, to better predict the clinical outcome of ADCs.