Evolution of the Platform PBPK Model for Monoclonal Antibodies Towards Pediatric Population
Dhaval Shah Assistant Professor at SUNY Buffalo
The presentation will introduce a platform PBPK model developed for monoclonal antibodies (mAbs). Ontogeny related changes in the physiological parameters responsible for mAb disposition will be discussed. Incorporation of the age related changes in these parameters into the platform PBPK model will be demonstrated in order to develop the pediatric PBPK model for mAbs.