A Reusable PBPK–QSP Platform for AAV and LNP Gene Therapy: Getting Dose and Tissue Targeting Right
Alvaro Ruiz-Martinez, PhD, Senior Modeler, Rosa & Co. LLC
Dr. Alvaro Ruiz-Martinez has twelve years of computational and modeling experience related to mechanical, chemical, and biological systems. He has developed models focused on immuno-oncology, biopolymer assembly, and pharmacokinetics and pharmacodynamics. Dr. Ruiz-Martinez received his Ph.D. in Mechanical Engineering from the University of California, San Diego, and his postdoctoral degree from Johns Hopkins University.
Gene therapy teams are still making high stake AAV and LNP dose choices from sparse, noisy mouse and NHP data. This webinar shows how a reusable PBPK–QSP platform turns those data into defensible human dose and tissue targeting decisions. Using an intravenous AAV case that spans mouse, NHP, and human, we will walk through how one transparent model structure can support both AAV and targeted LNP programs.